A Miniature American Shepherd Health Testing Guide​​


 
                            Items #1 through #5 are required for the OFA's CHIC qualifications.

    
#1  Tattoo or Microchip 

     
The dog must have a permanent ID to participate in the OFA's CHIC Program.  
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    #2  HD - Hip Dysplasia
- x-rays - OFA or PennHip

      
*OFA - The Dog must be at least 24 months of age to get a permanent Hip Dysplasia evaluation number
                             for the x-rays performed with OFA.


      
*PennHip - The dog should be at least 6 months of age to get a permanent Hip Dysplasia evaluation.  
                            PennHip does not need to be redone after 24 months. 


                   When submitting the PennHip results into the OFA you must include the fee of $25 and a signed note requesting
                   the results be entered into the CHIC program for the OFA database.

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#3  Eye Examination by an ACVO Ophthalmologist

 
    The ECR eye exam should be done in the same year as you are entering the dog into the CHIC program.   Your dog must
         pass the eye exam or you must check the box to "release the information to the public" on a dog that did not pass, for that
         dog to participate in the CHIC program. 

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 #4  prcd/PRA - Progressive Retinal Atrophy - DNA Test - Eye Disorder - Autosomal Recessive
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#5  MDR1 - Multiple Drug Sensitivity - DNA Test - Autosomal Incomplete Dominant    
 
 
   
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Items #6 through #24 are optional testing for our breed & for the OFA's CHIC Program. 

          Breeders should be using most of the available health testing on their parent dogs.  The testing listed below can also be
             added to your dog's information on the OFA's database website.   The laboratory must be an acceptable OFA facility
for
             that DNA test.   Submit the Health Testing and the DNA test results with the appropriate fees.


     
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#6  CMR1 - Canine Multi-Focal Retinopathy 1 - DNA Test - Eye Disorder - Autosomal Recessive
    
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#7   DCM - Dilated Cardiomyopathy - DNA Test - Affected Genes: PDK4   THIS TEST IS NOT FOR OUR BREED!    
           Inheritance:  Autosomal Dominant With Incomplete Penetrance - Breed(s): Doberman Pinscher.
 
        
  If a Miniature American Shepherd or Mini Australian Shepherd test results are a Carrier or Affected for this mutation,
              it means absolutely NOTHING!   This PDK4 test only pertains to the Doberman Pinscher breed of dog.
 

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#8  Elbow Dysplasia - OFA x-ray Evaluation.    This x-ray can be done at the same time as the Hip x-rays are performed.
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#9  HSF4-2 - Hereditary Cataracts - DNA Test - Eye Disorder - Autosomal Dominant  With Incomplete Penetrance
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#10  DM - Degenerative Myelopathy - DNA Test -  Autosomal Recessive with Incomplete Penetrance 
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#11  NCL6 (CLN6 Gene) - Neuronal Ceroid Lipofuscinosis 6 - (Batten disease)- DNA Test - Autosomal Recessive                         Hereditary Neurodegenerative disease.  OFA may list the results as "Cerebellar Ataxia (NCL-A)".
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#12  NCL8 (CLN8 Gene) - Neuronal Ceroid Lipofuscinosis 8 (Australian Shepherd type) - DNA Test -
                 Autosomal Recessive  (Amaurotic idiocy, Batten disease) 

       
Affected dogs lack a specific Enzyme necessary for normal cellular metabolism.  This form of NCL is found in the endoplasmic
          reticulum.

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 #13  CD - Cone Degeneration - DNA Test - Eye Disorder - Autosomal Recessive
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 #14  CEA - Collie Eye Anomaly - Choroidal Hypoplasia - DNA Test - Eye Disorder - Autosomal Recessive With
              Variable Expressivity.
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#15  CDDY - Chondrodystrophy (FGF4-12) - DNA test - Semi-Dominate Trait for height. 

​           
With respect to IVDD the inheritance follows a Dominate mode.  "Since some of the breeds identified in this study
               segregated the CDDY mutation, the relative risk for disc herniation was calculated.  It varied from 5.5 (Chihuahua)
               to 15.1 (mixed breed).   This means that a dog with 1 or 2 copies of CDDY is 5-15 times more likely to have a disc
              herniate then a dog without the mutation."   
                https://www.vgl.ucdavis.edu/services/dog/Managing%20the%20genetics%20of%20CDDY.pdf
              Susceptibility to "Hansen's Type I" intervertebral disc disease that could cause problems for a young adult dog.  
              Dogs that have both FGF4-12 and FGF4-18 mutations may show a more drastic reduction of leg length.   

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#16  CDPA - Chondrodysplasia  (FGF4-18) - DNA test - Incomplete Dominant Mode.

           
It can cause the short legged phenotype & could also cause crooked front teeth in a number of breeds. 
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#17  GCS - Gray Collie Syndrome - DNA test - Cyclic Neutropenia - Autosomal recessive mutation.  

            
An abnormal stem cell formation in the dog’s bone marrow.
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#18   HUU - Hyperuricosuria (SLC2A9 Gene) is also known as Urolithiasis - DNA Test - Autosomal Recessive  

             
Uric acid can form crystals and/or stones (uroliths) in the urinary tract.
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#19   ICM -  Intestinal Cobalamin Malabsorption (AMN Gene) - DNA Test - Autosomal Recessive 
 
            The condition makes the dog unable to absorb certain nutrients resulting in a "Failure to thrive". 
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#20  Dentition Database - Teeth Count Exam  

          
Adult teeth must be fully erupted for evaluation.  Have your dog's teeth counted by a licensed veterinarian.
              Print off OFA's Dentition form and take it with you to the next vet appointment. 

     -------------------------------------------
  
#21 Natural Bobtail - NBT is a T gene mutation C189G - DNA Test - Autosomal Dominant trait.  

​          
Dogs that have 1 normal copy & 1 copy of the C189G mutation (heterozygotes) are a genetically short-tailed animal.
              
Receiving 2 copies of the C189G mutation is considered to be lethal.

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 #22  Patellar Luxation - Rear Legs Joint (stifle) Evaluation 

           
The dog should be at least 12 months of age for a permanent evaluation. "Exams on animals under 12 months of age
                are considered preliminary evaluations and are not eligible for OFA numbers."  Download the OFA Patellar Luxation
                form on OFA's website and take it with you to your next veterinarian visit.

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 #23  Merle Color Testing -  Merle coat color - DNA Test - Autosomal Dominant. 

         
Tilia Laboratories is the preferred laboratory for the merle DNA testing.  
                https://www.tilialaboratories.cz/index.php?page=00101&d=PES&dp=PES339&pismeno=M&lang=uk&typvys=1

           
It's very important to order this merle booklet either before or after you receive your merle test results.   Go to this link to learn about
              the merle genes.
   https://www.merle-sine-insertion-from-mc-mh.com
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#24  OFA Canine Thyroid Profile - Only use an approved OFA Canine Thyroid Laboratory to obtain a certification. 

               
Submission of chilled or frozen blood serum by your veterinarian is required. 
                     MSU laboratory test is at the printable link: 
                             https://animalhealth.msu.edu/Bin/Catalog/Catalog_Test.exe?Action=Print&ID=1629  

                  The dog should be at least 12 months of age.  https://www.ofa.org/diseases/other-diseases/hypothyroidism

     ___________________________________________________________________​

           
New discoveries in Dog health testing are being discovered every year.   ​So this list will continue to grow.  

        
When you send the health test results to the OFA, you'll need to include the submission fees for all of the Normal and some
            of the Carrier tests.   Contact the OFA for the submission discounts and pricing on 3 or more submitted tests.

            *The OFA will not accept all test results from all laboratories - some of the tests are subjective to patents.  

        
This link lists a majority of the laboratories that the OFA does accept for our breed & this may be a partial list:
                                            https://www.ofa.org/diseases/dna-tested-diseases/all-dna-tests



            
If you have any questions regarding the CHIC program or the qualifying laboratories contact:
                        Orthopedic Foundation for Animals, Inc.
                        2300 East Nifong Blvd.
                       Columbia, MO 65201-3806 (800) 442-0418 or 573-442-0418
                       Email: chic@offa.org               Website: www.ofa.org

                            ____________________________________________________
_______________________________________________

             Breeders can submit their dog's qualifying health testing results into the Orthopedic Foundation for Animals (OFA).
                 They can also participate in the CHIC Program.   All of our dogs participate in the OFA’s CHIC program.   Our dog's
                 health testing results are available for the public to see!  I would love to see more of the "Mini" breeders participate
                 in the OFA!

Web Page Updated 2/6/2020